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KMID : 0388419960060010067
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Konkuk Journal of Medical Sciences
1996 Volume.6 No. 1 p.67 ~ p.82
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Experimental Study of the Effect of Bronchodilator Inhalaton Therapy in Acute Lung Injury Model
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Abstract
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The acute respiratory distress syndrome(ARDS) is a disorder of diffuse lung injury secondary to a wide vareity of clinical insults(e. g sepsis) and is manifested by impaired oxygenation, pulmonary edema, and decreased static and dynamic
compliance.
Reduced lung compliance is a hallmark of the syndrome and has generally been considered the primary lung mechanics abnormality. We designed this study to confirm the presence of decreased lung compliance in animal model with acute lung injury and
to
determine whether these changes are reversible using an aerosol beta-agonist such as salbutamol and nicorandil.
We studied 6 dogs with oleic acid I duced acute diffuse lung injury. We measured hemodynamic data, dynamic compliance, arterial blood gas analytic data during the experiment.
Lung compliance and other lung mechanics and hemodynamic data are impaired with acute lung injury of experimental dogs. Aerosolized beta agonist significantly increased the lung compliance and tend to improved the gas exchange mechanics.
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KEYWORD
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